Blar i forfatter "Jenssen, Trond"

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    • Ambulatory blood pressure as risk factor for long-term kidney function decline in the general population: a distributional regression approach 

      Eriksen, Bjørn Odvar; Fasiolo, Matteo; Mathisen, Ulla Dorte; Jenssen, Trond; Stefansson, Vidar Tor Nyborg; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-31)
      The results of randomized controlled trials are unclear about the long-term efect of blood pressure (BP) on kidney function assessed as the glomerular fltration rate (GFR) in persons without chronic kidney disease or diabetes. The limited duration of follow-up and use of imprecise methods for assessing BP and GFR are important reasons why this issue has not been settled. Since a long-term randomized ...

    • Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population 

      Melsom, Toralf; Norvik, Jon Viljar; Enoksen, Inger Therese; Stefansson, Vidar Tor Nyborg; Rismo, Renathe; Jenssen, Trond; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
      <i>Introduction</i> - Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used ...

    • Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival 

      Witczak, Bartlomiej J; Pischke, Søren E.; Reisæter, Anna V.; Midtvedt, Karsten; Ludviksen, Judith K; Heldal, Kristian; Jenssen, Trond; Hartmann, Anders; Åsberg, Anders; Mollnes, Tom E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      Background: The major reason for graft loss is chronic tissue damage, as interstitial fibrosis and tubular atrophy (IF/TA), where complement activation may serve as a mediator. The association of complement activation in a stable phase early after kidney transplantation with long-term outcomes is unexplored.<p> <p>Methods: We examined plasma terminal C5b-9 complement complex (TCC) 10 weeks ...

    • Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality 

      Heldal, Torbjørn Fossum; Åsberg, Anders; Ueland, Thor; Reisæter, Anna Varberg; Pischke, Søren Erik; Mollnes, Tom Eirik; Aukrust, Pål; Hartmann, Anders; Heldal, Kristian; Jenssen, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-30)
      In the general population, low-grade inflammation has been established as a risk factor for all-cause mortality. We hypothesized that an inflammatory milieu beyond the time of recovery from the surgical trauma could be associated with increased long-term mortality in kidney transplant recipients (KTRs). This cohort study included 1044 KTRs. Median follow-up time post-engraftment was 10.3 years. ...

    • No association between glycemia and wound healing in an experimental db/db mouse model 

      Berdal, Margrete; Jenssen, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Impaired wound healing is a frequent problem in diabetes. Hyperglycemia may be an operative mechanism, but a link between glycemic control and wound healing has never been established.Wounds in db/db mice have been extensively studied. This study was undertaken to see if plasma glucose was a predictor of wound healing. An excisional wound was made (149 db/db mice). Wound closure was studied versus ...

    • Systemic inflammation early after kidney transplantation is associated with long-term graft loss: a cohort study 

      Heldal, Torbjørn Fossum; Åsberg, Anders; Ueland, Thor; Reisæter, Anna Varberg; Pischke, Soeren; Mollnes, Tom Eirik; Aukrust, Pål; Reinholt, Finn P.; Hartmann, Anders; Heldal, Kristian; Jenssen, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-02)
      Background: Early graft loss following kidney transplantation is mainly a result of acute rejection or surgical complications, while long-term kidney allograft loss is more complex. We examined the association between systemic inflammation early after kidney transplantation and long-term graft loss, as well as correlations between systemic inflammation scores and inflammatory findings in biopsies 6 ...